Recent experimental work indicates latamoxef sodium used as a broadspectrum antibiotics generates oxygen-free radicals. The present study represents an attempt to investigate whether reperfusate containing Shiomarin(85% latamoxef sodium+15% mannitol) might decrease the post-ischemic recovery of cardiac function. In the investigati)?n, twelve isolated rat hearts were subjected to 270 minutes of cold total global ischemia. After the cold total global ischemia, six hearts(KHB group) were reperfused with Krebs-Henseleit buffer solution and the other six hearts(LMS group) with Krebs-Henseleit buffer solution containing latamoxef sodium(200ug /L).
Postischemic recovery rate of heart rate, aortic systolic pressure, aortic flow, coronary flow and cardiac output at 20 minutes reperfusion was 100.6610.38, 85.257.61, 78.956. 02, 78.858.86 and 79.116.54 percent respectively in the KHB group and 97.964.19, 87. 724.37, 81.746.80, 82.6910.01 and 81.906.67 percent respectively in the LMS group. The hemodynamic data revealed no significant difference in the post-ischemic recovery rate of the two groups. This finding suggests that reperfusate containing Shiomarin(latamoxef sodium, 200ug /L) does not affect the cardiac functional recovery after cold total global ischemia.
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